That is the danger of a blood clot, Covid an infection, or getting vaccinated

You are at a higher risk of getting blood clots if you contract Covid-19 than if you received the first dose of the Pfizer or AstraZeneca vaccine, new research shows.

In what is arguably the largest study of vaccine side effects to date, researchers at Oxford University analyzed the health data of more than 29 million people aged 16 and over who received their first doses of vaccine. The data was collected between December 2020 and April 2021

Researchers used routinely collected electronic health records to analyze the short-term risks (within 28 days) of hospitalization for blood clots and to look for complications after a patient was either infected or vaccinated.

The results of the study suggest that someone with coronavirus is almost nine times more likely to develop thrombocytopenia, a condition in which the patient has a low number of cells known as platelets that help blood clot someone who jab a dose of the AstraZeneca.

These results come a day after an investigation found that an award-winning BBC radio host died from complications from the AstraZeneca vaccination.

BBC Radio Newscaster host Lisa Shaw died in May at the age of 44, just over three weeks after receiving her first dose. Shaw developed a headache a week after the vaccination and then developed blood clots, which led to a hemorrhage in the brain

The coroner said Thursday that Shaw developed vaccine-induced thrombosis and thrombocytopenia, which has been described as a “rare and aggressive complication associated with the AstraZeneca vaccine” and has been classified as “the underlying cause of her death.”

Here’s what experts want you to know in light of new research on the risk of blood clots from coronavirus and Covid vaccines.

Serious side effects from vaccines are very rare

Julia Hippisley-Cox, professor of clinical epidemiology and general medicine at Oxford University and lead author of the new vaccine study, said Shaw’s death was “very sad” but that all potential risks of the vaccine must be compared to Covid-19 infection put in context.

“This is very sad and goes to Lisa’s family,” she told BBC Radio 4’s Today program. “But, to put it in context, these are very rare cases and the vast majority of patients will be using these vaccines be absolutely satisfied. “

An expert who was not involved in the research but a member of the Scientific Pandemic Influenza Group on Modeling (Spi-M), which advises the government, said there will always be “tragic cases” but it is “so much riskier, To catch Covid ”.

Dr. Mike Tildesley said he hoped the new study, which involved millions of people, “maintains confidence in the vaccines going forward.”

“Unfortunately there will always be the tragic cases like Lisa, but that still doesn’t mean that the risks of the vaccination are actually high, it’s still much riskier to catch yourself with Covid and develop a blood clot this way.” “He told BBC Breakfast.

This is how the risk of blood clots compares

Professor Aziz Sheikh, co-author of the study, said the increased risk of thrombocytopenia seen in her work is similar to other vaccines commonly used in the UK such as the flu shot.

Researchers estimated that 10 million people vaccinated with the AstraZeneca vaccination would experience 107 additional cases of thrombocytopenia in the 28 days following vaccination, compared to 934 in people with the virus.

The scientists found a link between those who received the Pfizer vaccine and an increased risk of stroke, but those with the virus were more than 10 times more at risk: an estimated 143 additional cases per 10 million people, compared with 1,699 Cases in those with Covid-19.

The newspaper also said that for every 10 million people vaccinated with AstraZeneca, there were an estimated seven additional cases of CVST, while there were 20 in people with Covid-19. For clotting in a vein, they estimated 66 additional cases per 10 million people vaccinated with AstraZeneca, compared to about 12,614 in those infected with Covid-19.

Neither vaccine was associated with blood clots in an artery, either, while there were about 5,000 cases for every 10 million people infected with Covid.

Prof. Hippisley-Cox said the identified increased risks only existed for a short time after vaccination, compared to a longer period of time if infected with the virus. “Pfizer had an increased risk of stroke as early as 15 to 21 days after vaccination. And for thrombocytopenia with AstraZeneca it was eight to 14 days, ”she said.

“They were very specific, short periods of time, while associations with infection generally seemed to persist for a full 28 days after infection.”

Most of the side effects of the vaccine are very mild

The fear of blood clots after vaccination has led to some vaccination delay and, in particular, the use of the Oxford-AstraZeneva vaccine in a number of other countries has been restricted.

According to an earlier study published in the medical journal Lancet in July, the Astra-Zeneca Covid-19 vaccine does not increase the risk of infrequent blood clotting after a second dose.

In the UK, more than 90 million doses of vaccine have been given to date – 47,860,628 people received their first dose (88% of those over 16) while 42,860,628 people are fully vaccinated – more than three-quarters of the adult population.

According to an analysis of the data from the Zoe Covid Symptom Study App, only one in four people experience side effects after receiving either vaccine, which lasts one to two days.

The vaccines have been extensively tested

All three Covid-19 vaccines currently used in the UK – AstraZeneca, Pfizer BioNTech and Moderna – have undergone randomized clinical trials large enough to detect very rare side effects.

Regulators will conduct a risk-benefit analysis of the drug to assess the risk of side effects when uncovering rare events such as: B. a blood clot, with the benefits of avoiding the disease.

In fact, analysis of the Zoe Covid Symptom Study App data reassuringly found fewer side effects in the general population with both Pfizer and AstraZeneca vaccines than reported in clinical studies by their manufacturers.

The researchers on the new vaccine study were independent of the Oxford University team that worked with AstraZeneca to develop its vaccine.

Vaccination is still the best protection for yourself – and others

According to the latest information from Public Health England, vaccines are now estimated to have prevented more than 100,000 deaths.

Prof. Aziz Sheikh, co-author of the University of Oxford study, said the results “clearly underscore” the importance of getting vaccinated to reduce the risk of these clotting and bleeding results. Vaccinations offer “significant public health benefits”.

“People should be aware of these increased risks after a Covid-19 vaccination and immediately consult a doctor if symptoms occur, but also be aware that the risks of infection with SARS-CoV-2 are significantly higher and over longer periods of time Professor Hippisley-Cox concluded.

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